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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RUNX1T1 All Species: 28.79
Human Site: S222 Identified Species: 70.37
UniProt: Q06455 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q06455 NP_004340.1 604 67566 S222 E Q L L L D A S T T S P V D S
Chimpanzee Pan troglodytes XP_528188 799 88187 S417 E Q L L L D A S T T S P V D S
Rhesus Macaque Macaca mulatta XP_001090215 652 70879 S273 E Q L L L D A S A S S P I D S
Dog Lupus familis XP_850414 604 67397 S222 E Q L L L D A S T T S P V D S
Cat Felis silvestris
Mouse Mus musculus Q61909 577 64319 S203 T T S P V D S S E L L L D V N
Rat Rattus norvegicus NP_001102127 577 64303 S203 T T S P V D S S E L L L D V N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505430 605 67678 S222 E Q L L L D A S T T S P V D S
Chicken Gallus gallus Q5F3B1 591 64855 N214 E Q L L L D A N A S S P I D S
Frog Xenopus laevis Q9IAB2 586 65036 S204 E H I L L N T S T S S P A D S
Zebra Danio Brachydanio rerio NP_001070244 588 65517 S202 E Q L L L D T S T T S P V D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 73.9 66.2 99.1 N.A. 94.6 94.3 N.A. 97.3 74.1 60.4 87.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 74.9 77.3 99.1 N.A. 94.8 94.6 N.A. 98.6 82.6 74.1 92.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 80 100 N.A. 13.3 13.3 N.A. 100 73.3 60 93.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 100 N.A. 33.3 33.3 N.A. 100 93.3 80 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 60 0 20 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 90 0 0 0 0 0 0 20 80 0 % D
% Glu: 80 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 20 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 70 80 80 0 0 0 0 20 20 20 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 10 0 0 0 0 0 0 20 % N
% Pro: 0 0 0 20 0 0 0 0 0 0 0 80 0 0 0 % P
% Gln: 0 70 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 20 0 0 0 20 90 0 30 80 0 0 0 80 % S
% Thr: 20 20 0 0 0 0 20 0 60 50 0 0 0 0 0 % T
% Val: 0 0 0 0 20 0 0 0 0 0 0 0 50 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _